#15 David Yost
David Yost Played the role of Blue Ranger in Power Rangers. He left the show due to some harassment for his sexual orientation.
#14 Shannen Doherty
Shannen Doherty was replaced by Rose McGowan from the cast of Charmed as she left the show due to an on-set arguments with her co-workers.
#13 Michael J. Fox
Michael J. Fox left Spin City due to his Parkinson's disease. Charlie Sheen replaced him in the show.
#12 Soleil Moon Frye
Soleil Moon Frye played the role of Punky Brewster on the kid's show with the same name. But due to a growth disorder, she grew older early and no longer looked a young girl at the age of 16, as she was a fully-grown lady.
#11 Brandon Lee
Brandon Lee was shooting for the film The Crow, when a tragic incident took his life. Mistakenly one of the crew member loaded the revolver with the wrong cartridge, due to which Lee died. However, the film wasn't shut down and it's story was a bit modified.
#10 Paul Walker
Paul Walker died while shooting the film Fast and Furious 7. However the film was completed by doubling some of his stunts and the remaining by computer effects.
#9 John Ritter
John Ritter died due to a heart attack while shooting his sitcom. But he wasn't replaced in the show, 8 Simple Rules for Dating My Teenage Daughter, instead he was shown dead in the series.
#8 Phil Hartman
Phil Hartman died while filming for NewsRadio. The show still continued and the first show after his death was a tribute to him.
#7 Jay Thomas
Jay Thomas was fired from the show Carla's husband Eddie for asking combat pay for his role of Carla's husband.
#6 Maude Flanders
Maude Flanders was the wife of Ned Flander who lived out of the state and the producers didn't agree to pay for her flights. So she had to leave this mortal plane.
#5 Tommy Chong
Tommy Chong had to leave the role of Leo as he was put behind the bars for selling drug paraphernalia.
#4 Steve Burns
Steve Burns left Blues Clues as he was asked to go bald in the show and he refused to it.
#3 Mr. Hooper
Mr. Hooper died while filming for Sesame Street. He had an iconic character in the show, so the makers decided to shoot a special episode to explain his death.
#2 Scarlett Pomers
Scarlett Pomers left the show Reba for getting the treatment for anorexia. She played the role of Kyra in the show.
#1 William Hartnell
William Hartnell played the first Doctor in the show doctor Who. But he was quite old to work so he decided to leave the show. However, the writers came with the idea of regenerating him into a young actor. This made them to switch the Doctor's appearance without changing the character.
